Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an hidden munitions depot in Syria employed by the Islamic State group (IS), as stated by the UK's MoD.
The site, located using reconnaissance, was assessed as containing munitions and bombs, the statement said, and was located in hills just above Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to target a several access tunnels leading to the facility... initial indications indicate the target was engaged successfully," the ministry announced.
There was no evidence of any civilian impact in the attack conducted Saturday night and each participating jet returned safely, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
IS - referred to as the so-called Islamic State - established militant control over significant areas in Iraq and Syria until 2019.
"This strike underscores British leadership, and resolve to work closely with our partners, to eliminate any revival of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey said.
RAF aircraft have conducted patrols over Syria to "forestall any attempted resurgence" of the group after its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of the UK armed forces involved in this strike for their professionalism and their courage," the Defence Secretary added. "They were among thousands of UK service members stationed over Christmas and New Year. This action, to remove terrorist threats who threaten our safety, highlights how UK forces are prepared to act, throughout the year, keeping Britain secure at home and powerful internationally."
During December, the US military executed what it described as a "major assault" against Islamic State objectives in the country, subsequent to an attack killed two US servicemembers and a civilian linguist in Palmyra.
The U.N. estimates Islamic State still has an estimated 5,000 to 7,000 fighters in Syria and Iraq.
